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Please use this identifier to cite or link to this item: http://eprint.iitd.ac.in/handle/2074/1124

Title: The effect of composition of poly(acrylic acid)–gelatin hydrogel on gentamicin sulphate release: in vitro
Authors: Changez, Mohammad
Burugapalli, Krishna
Koul, Veena
Choudhary, Veena
Keywords: Hydrogel
Interpenetrating polymer network
Controlled release
Gentamicin sulphate
Issue Date: 2003
Citation: Biomaterials, 24(4), 527-536
Abstract: Hydrogels based on poly(acrylic acid) and gelatin crosslinked with N,N′-methylene bisacrylamide (0.5 mol%) and glutaraldehyde (4%), respectively, forming an interpenetrating network were employed as matrices, for studying the loading and release of gentamicin sulphate. The release kinetics of gentamicin sulphate was evaluated in water (pH 5.8), phosphate buffer (pH 7.4) and citrate buffer (pH 4) at 37±0.1°C. The drug release in phosphate buffer was faster as compared to water or citrate buffer. Fitting the data of release studies in Peppas model indicated that the release of drug from full IPNs in phosphate buffer (pH 7.4), water (pH5.8) and citrate buffer (pH 4) were diffusion controlled. However, semi-IPNs showed both anomalous and Fickian diffusion mechanisms. With increasing gelatin percentage in the polymer, rate of drug release was faster and almost 85% of the loaded drug was released within 7 days in phosphate buffer (pH 7.4).
URI: http://eprint.iitd.ac.in/dspace/handle/2074/1124
Appears in Collections:Biomedical Engineering [CBME]

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