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Please use this identifier to cite or link to this item: http://eprint.iitd.ac.in/handle/2074/1201

Title: Synthesis, characterization, and blood compatibility of polyamidoamines copolymers
Authors: Dey, Ratan K
Ray, Alok R
Keywords: Hemocompatibility
Hemolysis
Heparin
Polyamidoamine
Blood compatible polymers
Issue Date: 2003
Citation: Biomaterials, 24(1), 2985-2993
Abstract: This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N′-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to their poor mechanical strength. In order to overcome this lacuna, copolymers of amidoamine with methylmethacrylate (MMA) were prepared. Characterization studies indicated that the PAAs have been suitably incorporated into the MMA matrix. The relative hydrophilic nature of the synthesized copolymers was established from the measurement of water contact angle. The heparinized copolymers showed significant improvement in non-thrombogenic characteristics.
URI: http://eprint.iitd.ac.in/dspace/handle/2074/1201
Appears in Collections:Biomedical Engineering [CBME]

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