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Please use this identifier to cite or link to this item: http://eprint.iitd.ac.in/handle/2074/1338

Title: An efficient synthesis of N3,4-diphenyl-5-(4-fluorophenyl)-2-isopropyl-1H-3-pyrrolecarboxamide, a key intermediate for atorvastatin synthesis
Authors: Pandey, Pramod S
Rao, T Srinivasa
Keywords: Atorvastatin
Munchnone
1,3-Dipolar cycloaddition
1,3-Oxazolium-5-olate
N-Debenzylation
Issue Date: 2004
Citation: Bioorganic & Medicinal Chemistry Letters, 14(1), 129-131
Abstract: An efficient synthesis of N3,4-diphenyl-5-(4-fluorophenyl)-2-isopropyl-1H-3-pyrrolecarboxamide, a key intermediate for the synthesis of an effective HMG-CoA reductase inhibitor atorvastatin, is described. The synthesis is based on the 1,3-dipolar cycloaddition reaction of mesoionic munchnone (1,3-oxazolium-5-olate) with N1,3-diphenyl-2-propynamide leading to N-benzyl pyrrole, and N-debenzylation using sodium in liquid ammonia as key steps.
URI: http://eprint.iitd.ac.in/dspace/handle/2074/1338
Appears in Collections:Chemistry

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