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Please use this identifier to cite or link to this item: http://eprint.iitd.ac.in/handle/2074/1380

Title: Quantitative EEG analysis for assessment to ‘plan’ a task in amyotrophic lateral sclerosis patients: a study of executive functions (planning) in ALS patients
Authors: Santhosh, Jayashree
Bhatia, Manvir
Sahu, Shweta
Anand, Sneh
Keywords: Amyotrophic lateral sclerosis (ALS)
Electroencephalogram (EEG)
Event-related desynchronisation (ERD)
Executive functions of brain
Brain–computer interface system (BCI)
Issue Date: 2004
Citation: Cognitive Brain Research, 22(1), 59-66
Abstract: An attempt has been made to study the ability of patients with amyotrophic lateral sclerosis (ALS) to ‘plan’ a task. Electroencephalogram (EEG) data corresponding to ‘planning of a movement task’ is analyzed in comparison with a normal relaxed state. The study was conducted on 12 patients with ALS (6 males, 3 females, mean age 46.75 years) and on same number of controls (10 males, 2 females, mean age 48.75 years) to evaluate a difference in the ability to ‘plan’ a movement task between them. Patients with ALS were divided in two groups defined by unclear/clear speech. It has been observed that patients with ALS having unclear speech (Group I) showed considerable reduction (p<0.0001) in ‘planning’ a movement task, whereas patients with ALS having clear speech (Group II) showed no deficit in ‘planning’ a movement task (p=0.0577), both in comparison with age-matched controls. Apart from supporting the earlier reports of a possible extended neuronal degeneration across wide area of the frontal lobes, the findings reveal a possible reduction in planning, an executive function of the prefrontal cortex of brain, and also reveal that speech impairment may be associated with cognitive deficits in patients with ALS.
URI: http://eprint.iitd.ac.in/dspace/handle/2074/1380
Appears in Collections:Biomedical Engineering [CBME]

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