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| Title: | The detailed molecular mechanism of ATP synthesis in the F0 portion of ATP synthase reveals a non-chemiosmotic mode of energy coupling |
| Authors: | Nath, Sunil
Jain, Siddhartha |
| Keywords: | ATP synthase
Oxidative phosphorylation
F0
Torsional mechanism
Ion translocation
Energy transduction
Energy storage
c-Subunit
Twist
Rotation-twist-tilt energy storage mechanism
Chemiosmotic theory |
| Issue Date: | 2002 |
| Citation: | Thermochimica acta, 394(1-2), 89–98 |
| Abstract: | Based on our torsional mechanism of ion translocation, energy transduction and energy storage in ATP synthase [Curr. Sci. 75(1998) 716]; [Curr. Sci. 77 (1999) 167]; [Curr. Sci. 78 (2000) 23]; [Biochem. Biophys. Res. Commun. 272 (2000) 629]; [FEBS
Lett. 476 (2000) 113]; [Thermochim. Acta 378 (2001) 35], the molecular mechanism for rotation of the c-rotor and the subsequent
rotation of the c-subunit and the c-subunit has been proposed. The details of the elementary steps involved in ion translocation and energy conversion in the F0 portion ofATP synthase have been provided. Electrostatic effects drive the rotation of the c-subunits in steps of 15◦ each during proton binding as well as unbinding. During the rotation of the c-rotor, the energy of the ion gradients is transiently stored as twist in the c-subunits, and finally as torsional strain in the c-subunit. The mechanism has
been shown to be consistent with a general kinetic analysis of ATP synthesis by ATP synthase. The detailed m... |
| URI: | http://eprint.iitd.ac.in/dspace/handle/2074/484 |
| Appears in Collections: | Biochemical Engg. and Biotechnology
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