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Please use this identifier to cite or link to this item: http://eprint.iitd.ac.in/handle/2074/504

Title: Optimization of compactin production in chemically defined production medium by penicillium citrinum using statistical methods
Authors: Chakravarti, R
Sahai, V
Keywords: Compactin
Penicillium citrinum
Plackett-Burman design
Central composite rotatable design
Response surface plots
Regression coefficients
Issue Date: 2002
Citation: Process Biochemistry, 38(4), 481-486
Abstract: Production of compactin by Penicillium citrinum was optimized using Plackett-Burman and central composite rotatable design.Out of 11 factors studied by Plackett-Burman design, six influenced the compactin production. Central composite rotatable design was used to optimize the significant factors and response surface plots were generated. Using these response surface plots and point prediction, optimized values of the factors were determined and a maximum compactin production of 490 mg/l was predicted. An experimental study using the optimized parameters resulted in production of 456 mg compactin per l,93% of the predicted value.
URI: http://eprint.iitd.ac.in/dspace/handle/2074/504
Appears in Collections:Biochemical Engg. and Biotechnology

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