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http://hdl.handle.net/2074/657
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| Title: | A continuous process for production of d-ribulose-1,5-bisphosphate from d-glucose |
| Authors: | Bhattacharya, Sumana
Nayaka, Amiya
Gomes, James
Bhattacharya, Sanjoy K |
| Keywords: | RuBP production
Bioreactors
Carbon dioxide fixation start-up
Immobilized enzymes |
| Issue Date: | 2004 |
| Citation: | Biochemical Engineering Journal, 19(3), 229–235 |
| Abstract: | A continuous bioprocess for production of d-ribulose-1,5-bisphosphate (RuBP) using d-glucose as starting material is described. Based on ideal plug-flow reactor modeling using kinetic parameters, a series of plug-flow reactors were designed. A cohort of enzymes namely,hexokinase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase (6PGDH), ribose-5-phosphate isomerase (RPI) and phosphoribulokinase, purified, immobilized and resident in five successive plug-flow reactors enables a series of conversion resulting in
an overall 60% yield of RuBP from d-glucose. Continuous conversion using this series of reactor provides a convenient route to produce RuBP in large quantities that could be used as starting material in other bioprocesses. |
| URI: | http://eprint.iitd.ac.in/dspace/handle/2074/657 |
| Appears in Collections: | Biochemical Engg. and Biotechnology
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| bhattacon2004.pdf | | 2026Kb | Adobe PDF | View/Open |
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