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dc.contributor.authorGiridhar, R
dc.contributor.authorSrivastava, Ashok K
dc.date.accessioned2005-07-01T11:50:27Z
dc.date.accessioned2019-02-09T07:12:15Z
dc.date.available2005-07-01T11:50:27Z
dc.date.available2019-02-09T07:12:15Z
dc.date.issued2001
dc.identifier.citationProcess Biochemistry, 36, 829-834en
dc.identifier.urihttp://localhost:8080/xmlui/handle/12345678/426
dc.description.abstractL-sorbose fermentation is of industrial importance since it is an intermediate step in the industrial production of vitamin C. It involves the biological oxidation of D-sorbitol to L-sorbose using Acetobacter suboxydans. Batch sorbose fermentation features substrate inhibition and hence it is impossible to obtain high sorbose productivity in batch bioreactors. Fed-batch fermentations can eliminate substrate inhibition and improve sorbose productivity. Fed-batch sorbose fermentations were conducted using two different nutrient feeding strategies. Fed-batch fermentation conducted by feeding nutrients containing 600 g1 of sorbitol at a constant feed rate of 0.6 l yielded a sorbose productivity of 12.64 g1-h. While fed-batch fermentation conducted by feeding nutrients containing 600 g1 of sorbitol at a linearly decreasing feed rate (0.5–0.041 h) demonstrated a productivity of 17.01 g1 h. The productivity obtained by feeding nutrients at a linearly decreasing feed rate was higher than that obtained by the constant fed-batch fermentation and, therefore, is a better substrate feeding strategy for improving sorbose productivity.en
dc.format.extent246054 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.subjectAcetobacter suboxydansen
dc.subjectFed-batch fermentationen
dc.subjectVitamin Cen
dc.subjectSorbitolen
dc.subjectSorboseen
dc.subjectFeeding strategyen
dc.titleComputer coupled substrate feeding strategies for efficient conversion of D-sorbitol to L-sorbose in fed-batch cultureen
dc.typeArticleen


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